Current Awardees

Bioactive Titanium for Improved Osseointegration and Stability of Orthopedic Hardware

Harnessing Endogenous Skeletal Stem Cells for Hyaline Cartilage Regeneration

Advancing Patient-Derived Organ-Dish Platforms for Precision Therapy in Inflammatory Bowel Disease

FreezOpt Sand-Mediated Cryopreservation System

SN101 Cell Therapy for Osteoarthritis Pain: A Head-to-Head Preclinical Comparison

Generation of Hypoimmune iPSC Seed Stocks for Clinical Applications

A Complete Bioprocess for the Scalable Production of Extracellular Vesicles from Induced Pluripotent Stem Cells

Expansion of the OASIS Clinical Trial to Phase III Pivotal: Evaluation of OsteoAdapt SP for Single-Level Lumbar Interbody Fusion

Standardized Compound Exposure Protocol for Multi-Region Brain Organoids

Programming Adipocyte Stem Cells to Treat Obesity & Metabolic Disease

High-Throughput Spatial Multimodal Genetic Screens in Human and Mouse Neurons

Purified Mesenchymal Progenitor Cell Therapies for Spine Fusion

Engineering Stem Cell Extracellular Vesicles for Orally Bioavailable IBD Therapy

Targeting Cardiac Progenitors for Atrioventricular Septal Defects in Down Syndrome

Mechanistic Basis of AMBP Gene Therapy in Mitigating ALS Phenotypes In Vitro and In Vivo

Glycoengineered Extracellular Vesicles with Enhanced Production and MRI Detectability for Theranostic Applications

Investigating Nanotube-Mediated Intercellular Communication in Human iPSC Models of Alzheimer's Disease

Personalized Treatment of Corneal Endothelial Diseases using CRISPR/Cas9-edited, Patient-specific, iPSC-derived Corneal Endothelial Cells

Programmable m6A Epitranscriptomic Editing to Restore MYBPC3 Function in Human iPSC Models of Hypertrophic Cardiomyopathy

Mentor: Dr. Gabsang Lee

Defining Genetic Regulators and Phase Transitions of -Synuclein Pathology in Human Neurons

Mentor: Dr. Debasish Sinha

Exploring Inflammation and Lysosomal Dysfunction in CFH Y402H AMD Using iPSC-Derived RPE Cells

Mentor: Dr. Jeff Bulte

Imaging-Guided Extracellular Vesicle Nanoplatforms as Theranostic Agents for Neuroinflammation

Mentor: Dr. Chulan Kwon

A Novel Integrin-Piezo1 Axis Driving Fibro-Adipogenesis in Arrhythmogenic Cardiomyopathy

Mentor: Dr.  Xizhen Lian

Multidimensional Lipid Nanoparticle Engineering for Fetal Hemoglobin Reactivation via In Vivo Base Editing in Human Hematopoietic Stem Cells

Mentor: Dr. Gabsnag Lee

Chemical Compound Screening to Expand Muscle Stem Cells in hPSC-derived MYOrganoids for Regenerative Medicine

Mentor: Dr. Vasiliki Machairaki

Spatial Neuro-Lipidomics via MALDI-Imaging: Unraveling Treatment Heterogeneity in iPSC-Derived Alzheimer's Hindbrain Models

Mentor: Dr. Pan Li

Deciphering Functional Consequences of Schizophrenia-linked GRIN2A Rare Variants Using Human iPSC-Derived Neurons

Mentor: Dr. Kan Cao

Engineering Vascularized Nipple Areolar Complex Implants Using MSC-Derived Extracellular Vesicles

Mentor: Dr. Xinzhong Dong 

Therapeutic Base Editing of KCNQ2 for Adaptive Silencing in Chronic Pain

Toxoplasma Infection and Disease Modeling using Stem Cell Technology and Organoids

The Influence of RPE on Muller Cell Remodeling in Choroideremia

Mechanism and Treatment of Ventricular Contractile Reserve Dysfunction in Human Heart Failure

Label-Free Microfluidic Sorting of Stem-Cell-Derived Retinal Ganglion Cells for Glaucoma Research

Disease Mechanisms in TANC2-Related Disorder

Human Cardiac Pacemaker Organoids for Heart Rhythm Disease Modeling and Therapeutic Discovery

Establishing a Human iPSC-Based Experimental Platform to Study the Pathogenesis of Myotrem Myopathy

Developing a Therapeutic Strategy for Cardiac Laminopathy

A Novel Drug Discovery Platform To Treat Cardiac Arrhythmias

Illuminating the Etiology of Human Segmentation Disorders Using Stem Cell Derived Embryo Models

Induced Pluripotent Stem Cell Models of Alzheimers Disease Genetic Risk in the Locus Coeruleus

Understanding Drug-Induced Neurotoxicity Using Stem Cells

Toward Precision Biomarkers in RTT: Modeling Non-Cell-Autonomous Mechanisms with Patient iPSC to Develop Cross-Model Translational Biomarkers

Nanochon Chondrograft Manufacturing Buildout for Clinical Production

Development of a Centralized (GMP) Contract Development and Manufacturing Organization (CDMO) and iGRP Manufacturing

A High-throughput Instrument for Neurological and Psychiatric Drug Screening Using iPSCderived
3D Cultures

Accelerating the Next Generation Therapies for Inflammatory Bowel Disease 

Commercialization of in Vivo Pain-Relieving Human Pain-Sensing Neurons

A Phase 1/2a, Multicenter, Randomized, Controlled, Single-Blind, Dose-Finding Study to
Evaluate the Safety and Efficacy of BRC-OA, a Human Adipose Allograft, for Treatment of Knee
Osteoarthritis

Ultrasound Guided Micro-Fragmented Adipose Transfer Graft for Partial Thickness Rotator Cuff Tears, Single-Blind Randomized Controlled Trial

Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures in Short Telomere Syndromes

CHMP7 Antisense Oligonucleotide: Candidate Therapy for ALS/FTD Dementia and TDP-43 Proteinopathies

Validation of MoroPLUR Induced Totipotent Stem Cells for Generating Whole Human Eye Organs

Functional Validation of MoroPLUR Human Stem Cells in Clinical-Grade Conditions

Advancing Alzheimer's Disease Research with Organoid Intelligence: A Synaptic Plasticity and Learning-on-a-Dish Approach

Convergent Effects of Genetic and Inflammatory Risk Factors for Autism Spectrum Disorders on the Development of Human Purkinje Cells

Mannose Overexpression by mesenchymal Cancer Stem Cells as Imaging Biomarker for Tumor Aggressiveness

Advancing Remyelination Drug Discovery Using Human OPCs and Inhibitory Microenvironment Model

Autonomous Electrical Organoids for Treating Heart Rhythm Disorders

Molecular Regulation of Human Erythropoiesis by SIX

The Role of CHMP2B in NPC Injury and TDP-43 Dysfunction in Sporadic ALS

Human Stem Cell Models for Investigating Clonal Hematopoiesis of Indeterminate Potential (CHIP)

Nanopore sequencing of TET3-Deficient Neurons: A Path to Understanding DNA Methylation and Correcting it in Disease

Engineering Human Mesenchymal Stem Cell-Derived Exosome Mimetics for Osteoporosis Treatment 

Reversibility & Prevention of Axonal Dysfunction in Mutant hiPSC-Derived Neurons

Therapeutic Targets in Microglia for Prevention and Treatment of GBA1-Associated Parkinson's Disease

Human Marrow Stem-Cell Derived Pro-Inflammatory CAR-Myeloid Progenitors as Immunotherapy for Cancer

Finetuning of MSC Priming for Mucosal Healing in IBD: Dual Targeting Intestinal Stem Cell Regeneration and Immunomodulation

Glial Mitochondrial Dysfunction Contributes to the Pathogenesis of Neurodegenerative
Diseases

Human iPSC Derived Spinal Organoids in a Preclinical Model of Fetal Myelomeningocele Repair

Characterization of New 4-Factor Induced Schwann (4FiS) Cells and Testing its In Vivo Myelination

Investigating the Role of PKA Activation in Bipolar Disorder: Functional Characterization of AKAP11 Protein Truncating Variants in Genetically Engineered Human iPSCs

In Vivo Genome Editing in the Hematopoietic Stem Cells to Treat Sickle Cell Disease

Revealing the Genetic Drivers and Regulation of Human Hematopoietic Stem-Progenitor Cell Differentiation with a Systems Approach

A Human iPSC Platform for Investigating a Translationally Relevant P2X7R-Mediated ALS Target

Discovery of Cell Cycle Activators to Promote Myocardial Regeneration and Contractile
Function in Human Engineered Heart Muscles

Engineered iPSC-Derived Platelets as Clotting Factor Delivery Vehicles for Trauma Resuscitation

A Lactating Mammary Organoid Model from Human iPS Cells

Targeting HMGA1 Stem Cell Networks to Prevent Atherosclerosis in TET2 Clonal Hematopoiesis

Exploring the Role and the Therapeutic Potential of β1-Importin in Axonal Regeneration in ALS

Harnessing Stem Cell Technology to Understand Mitochondrial Neutropenia Through the Lens of Barth Syndrome

Deciphering the Link between Epigenetic Regulation and Lipid Metabolism in C9orf72-ALS/FTD Using iPSC and Organoid Models

Improved Engraftable Retinal Organoid Progenitors from TIRN Totipotent Stem cells

Mentor: Dr. Seth Ament

Implication of SETD1A Loss-of-Function in DNA Replication Stress During Neural Induction

Mentor: Dr. Elias Zambidis

Design and Validation of iPSC-based uniCAR Myeloid Progenitors as Versatile Tumor Immune Therapy

Mentor: Dr. Jorge Almodovar

Innovative Strategies for Schwann Cell Precursor Studies Using hiPSC-Derived Models on ECM Coatings: Advancing Myelination, Morphological Insights, and Neural Regeneration

Mentor: Dr. Ted Dawson

The Roles of MIF Nuclease Activity in Tau-Induced cGAS-STING Activation in hiPSC-Derived Microglia

Mentor: Dr. Graeme Woodworth

Mechanobiology of Confined Migration in Human Neural Stem Cells: In Vivo Visualization and Ex Vivo Mechanical Mapping

Mentor: Dr. Shuying Sun

The Role of TDP-43 Dysfunction in Neuroinflammation

Molecular Modulators of Autophagy

The Role of Fate-Determining Transcription Factor REST in Endothelial Differentiation

Biophysics of Mitochondrial Membranes in Cardiolipin-Deficient iPSCs: Pathophysiology and Treatment of Barth Syndrome (BTHS)

Investigating the Regulatory Role of NLRX1 in Inflammatory Reactive Astrocytes Derived from Human Stem Cells

Leveraging Human iPSC Models for Mechanistic Investigation of Chromatin Regulators Linked to Rare Neurodevelopmental Disorders

Extracellular Fluid Viscosity is a Novel Physical Cue that Regulates Human Mesenchymal Stem Cell Function

Effects of Early General Anesthetic Exposure on Neural Development: An In Vitro Study Using Human Induced Pluripotent Stem Cell Derived Brain Microphysiological System

A Human Neurodevelopmental Model for Investigating the role of STRADA in Inhibitory Neuron Cortical Lamination and Epilepsy

iPSC Platforms to Develop Genome Restoration Strategies Using Cas9-RC

Role of Lipid Metabolic Signatures in Induced Pluripotent Stem Cell Derived Alzheimer's Disease Neurons

Preclinical Investigation of Dysregulated Autophagy-Induced EMT Drives Secretoryautophagy and Ferroptosis in Human iPSC-Derived RPE Cells with the CFH402 Risk Allele

Automated Stem Cell Radiolabeling via 3D Microprinting-Enabled Microfluidics

Use of iPSC-Derived Smooth Muscle Cells to Identify Functional Defects in LRP1

Peripheral Lipid Metabolism as a Modulator of Synucleinopathies

Clinical Trial in a Dish: Identifying Novel Molecular Mechanisms and Translating Therapies for Lamin Cardiomyopathy

Vascular-Mimetic Devices for Vascularization and Monitoring of Human Neural Organoids

GMP Spinal Fusion Implant Manufacturing and QC Facility Build Out & Validation

Design, Build, and Qualification of a Stem Cell Manufacturing cGMP Suite

Development of Devices for 3D Culture and Banking of Human iPSCs and their Derivatives with High Viability and Function

Production of Neonatal Cardiac Mesenchymal Stem Cells to Treat Patients with Dilated Cardiomyopathy

Generation of Human iPSC and MSC Master Cell Banks and Derivative Products in an Enclosed GMP System

Clinical Development of a Universal Cure for Insulin-Requiring Diabetes

Agnos Therapeutics, Inc.

Development of Cellular Component Transfer (CCT) as a Treatment to Restore Vision in Retinitis Pigmentosa

Growing Human Liver in Pigs

Commercialization of an Affordable, Robust, and Biosafe bFGF Produced in Algae

OASIS: Clinical Investigation of OsteoAdapt SP in Single-level Transforaminal Lumbar Interbody Fusion (TLIF)

Stem Cell Therapy to Convert Stump Skin to Palmo-Plantar Skin in Amputees

Curate Processing of Hematopoietic Stem-Progenitor Cells for Gene Therapies

Validation of in Vivo Pain-Relieving Efficacies of Human Pain-Sensing Neurons

Validating the Utility of Pluripotent Stem Cell-Derived Corneal Endothelial Cells for Regulatory Approval by FDA

Validation of MoroPLUR TIRN-hiPSC for Generating Animals with Human Lympho-Hematopoietic Systems 

Human GRPs As Drug Factories for Local Modulation Of Neuroinflammation In Cerebral Small Vessel Disease

Induced Pluripotent Stem Cell Derived Models for the Study and Treatment of CACNA1A Related Disorders

Computational Approach to In Vivo Genome Editing in the Brain

Developing and Improving Human Stem Cell-Derived Extracellular Vesicle Therapy for Brain Recovery After Cardiac Arrest

A Multifunctional Biocompatible Scaffold for Cell Replacement Therapy to Restore Vision in Optic Neuropathy

Elucidating Excitation-Inhibition Imbalance in Schizophrenia Using Patient-Derived Cerebral Organoids

Correcting Muscular Dystrophy Using Microexons

Modeling Neurodegenerative Diseases with a New Optical TMEM106B Aggregation in hiPSC-Derived Cortical Neurons

Smart Intravital Multiphoton Imaging iPSC-Derived Cells Grafted into Ischemic Brain Assisted by Empowered Helper Cells

Neuroprotection by An Endogenous Chaperone in a Stem Cell Model of Parkinson's Disease

Development of hiPSC-Derived Microglia Drug Screening Platforms for Alzheimer’s Disease

Tauopathy Therapy using FGL1 Delivery via Engineering iPS Cell-Derived Exosomes

Co-transplantation of MMP-9 Enhanced Mesenchymal Stem Cells and Pancreatic Islets for Treatment of Type-1 Diabetes

A Novel Stem Cell-Based Therapy Utilizing hiPSC-PNSorganoid-Derived Schwann Cells to Enhance Nerve Regeneration in VCA

Regenerative Cell Therapies for Radiation Injury

Pluripotent Stem Cell-Derived Trabecular Meshwork Cells as A Potential Treatment of Glaucoma

Mitigating Myopathy by Promoting Mitochondrial Fusion and Mitophagy

Repairing Human iPSC-Derived Blood Neural Barriers with TRPV4 Antagonists

Developing a CRISPR-Based Platform to Interrogate Enhancers & Super Enhancers

Efficient Generation of T Cells from iPSCs for Immunotherapy

Mechano-Biological Analyses of Human Neural Stem Cells in Confined Microenvironments  

Mentor: Dr. Hanseok Ko

Role of OSM OSMR Signaling in Human Microglia Astrocyte Axis Mediated Neurodegeneration in Parkinson Disease

Mentor: Dr. Miroslaw Janowski

Magnetic and Radioactive Labeling of Human Mesenchymal Stem Cells Secreting P2X7-Blocking Nanobody for their Precise Intra-Arterial Delivery in Stroke

Mentor: Dr. Aaron James

Endothelial Protein C Receptor Expression Identifies Perivascular Osteoprogenitors Modulated by WNT Signaling for Bone Regeneration

Mentor: Dr. Guanshu Liu

ModRNA-Delivering, Engineered Human iPSC-Derived Extracellular Vesicles for Image-Guided Targeted Treatment of Myocardial Infarction

Mentor: Dr. Yajie Liang

Multiphoton Imaging iPSC Derived NPCS Co-Transplanted with Helper Cells Expressing VEGF for Stroke Treatment

Mentor: Dr. Mingyao Ying

Modeling the Pathology and Transition of Patient-Derived A-Synuclein Strains in Human iPSC Cell-Derived Neurons

Mentor: Dr. MoonJung Jung

Epigenetic Regulation Underlying Chronic Alcohol-Induced Double-Stranded RNA Accumulation and Inflammation in Hematopoietic Stem Progenitor Cells

Mentor: Dr. Dian Arifin

Theranostic Mesenchymal Stem Cell-Derived Extracellular Vesicle-Liposome Hybrids as Adjuvant Therapy for Pancreatic Islet Transplantation

Mentor: Dr. Vasiliki Machairaki

MALDI-Imaging of iPSC-Derived Hindbrain Organoids as in Vitro Models for Alzheimer’s Disease and Drug Screenings

Develop A Satellite Cells-Specific AAV Vector for Duchenne Muscular Dystrophy Using A Human PSC-Based Platform

Development of hiPSC-Derived Odontoblast Scaffold for Future Cell Therapy In Dentin Regeneration

Building a Gene-Corrected, Personalized Approach to Corneal Transplantation

Tunable Viscoelastic Hydrogels to Enhance the Production & Immunomodulation of Mesenchymal Stem Cell-Derived Extracellular Vesicles 

Engineered MSCs-Derived Extracellular Vesicles as an Effective Microglia/Macrophage-Targeted Therapy for Hemorrhagic Stroke

hPSC-Derived Skeletal Muscle Organoid Transplantation as a Therapy for Duchenne Muscular Dystrophy

Cell-Type-Specific Proteome Analysis of Human Brain Organoid

New Human Cardiac Amyloidosis iPSC Lines Provide Novel Insight and Therapeutic Opportunities

Exploring the Contribution of The Placenta-Brain Axis to Neurodevelopmental Abnormalities In Down Syndrome

Dynamic MPI Cytometry of Mesenchymal Stem Cells in a Mouse Model of Multiple Sclerosis (MS)

Detecting The Effect of Genomic Risk for Schizophrenia on Placenta Development & Function, Using iPSC-Derived Trophoblast Cultures

The Role of Vascular Bed Stiffness in Regulating BBB Phenotypes in iPSC-Derived Brain Endothelial Cells

Enhancement of Capabilities of Existing Cytocentric Xvivo System Model 2 from
BioSpherix

Developing a Hematopoietic Stem Cell-derived Myeloid Cell Therapy for Solid Cancer

Generation of Immortalized Lymphoid Progenitors and Ready to use NK Cells from Human Induced Pluripotent Stem Cell (hiPSCs)

A Phase Ia Study of  LT2950 Tri-specific CAR T-cells for Patients with Relapsed/Refractory B-Cell Lymphomas

Mesenchymal Stem Cells for the Treatment of Ocular Graft versus Host Disease

Validation of the GPB Curate Cell Processing System for Manufacture of Therapeutic Hematopoietic Stem Cells

ROCK Inhibitor-Free 3D Culture and Cardiac-Differentiation of Human iPSCs and Banking of iPSC-Derived Cardiac Organoids

3D-Bioprinted Allograft-Polymer Hybrid Constructs for Bone Regeneration

Validating the Utility of Pluripotent Stem Cell-Derived Corneal Endothelial Cell Sheets in Endothelial Keratoplasty

Commercial Validation of Clinical-Grade Progenitors from TIRN hiPSC

FBN1-Deficiency Destabilizes Endothelial Cell-Cell Attachment and  Mechanosensing in Marfan Syndrome

In Vivo Tracking of Unlabeled MSCs and MSC-EVs for Rapid Clinical Translation

Bioengineered Cardiac Pacemaker Organoids

DACH as a Novel Human Megakaryopoietic Regulator

Establishing the Role of DNA Methylation Changes in Aged Human Blood Stem Cells by Xenotransplants

Novel use of Peripheral Blood-Derived Cells to Identify Individuals at High Risk of Developing PD

Human Marrow Stem-Cell Derived Pro-Inflammatory Myeloid Progenitors as Immunotherapy for Pancreatic Cancer

Human Pluripotent Stem Cell-Derived MYOrganoid for the Treatment of Volumetric Muscle Loss

Targeting a Novel Cocaine Receptor to Mitigate Cocaine Neurotoxicity

Microglial Infused Cerebral Organoid Cultures to Study Viral Infections of the CNS

CD141 Identifies Novel Mesenchymal stem/Progenitor Cell Subsets for Skeletal Tissue Engineering

Induced Pluripotent Stem Cell-Derived Extracellular Vesicles for Wound Healing

New Gene+Cell Therapy Platform Targeting Diabetes with Engraftable Skeletal Muscle Stem Cells

Transcriptomic Maturation of Human iPSC-Cardiomyocytes

In Vitro and in Vivo Characterization of Human PSC-Derived Lens Cells

A Versatile Human iPSC Platform for Modeling Corticospinal Motor Neuron Connectivity

Developing Novel Therapies for Osteogenesis Imperfecta using Growth Plate Organoids from Patient-Derived iPSCs

Developing Stem Cell Technology for Megakaryopoiesis and Platelet Production

Leveraging In-Vitro Organoid Model and Clinical Data to Examine Phenotypic Diversity in SYNGAP1 Intellectual Disability

Mentor: Dr. Xitiz Chamling

Investigating the Potential Contribution of Retinoic Acid Receptor-Related Orphan Receptor-Gamma Pathway in Oligodendrocyte Maturation and Myelination

Mentor: Dr. Jennifer Erwin

Neural Mechanisms of Schizophrenia using Variational Autoencoder Analysis of Induced Pluripotent Stem Cell-Derived Neural Networks

Mentor: Dr. Satoru Otsuru

Investigating the Changes in Mitochondrial Function and Energy Metabolism in Osteoblasts in Osteogenesis Imperfecta

Mentor: Dr. Ivy E. Dick

Evaluating the Pathogenic Mechanisms Underlying CACNA1A Disorders

Mentor: Dr. Ted Dawson

Contribution of Oligodendrocytic Cellular Milieu in Generation of A-Synuclein Strains in Multiple System Atrophy

Mentor: Dr. Xiaobo Mao

Spike Protein from SARS-CoV-2 Promotes Tauopathy Propagation and Neuroinflammation in Alzheimers Disease

Mentor: Dr. Brady Maher

Investigating the Effects of TCF4 Mutations During Oligodendrocyte Development and Maturation in a Human-Derived Model of Autism Spectrum Disorder

Mentor: Dr. Chulan Kwon

The Role of Splicing Factor Sf3b2 in Cardiomyocyte Maturation

Mentor: Dr. Valina Dawson

Role of MIF Nuclease in Neuroinflammation and Pathogenesis of Alzheimer's Disease

Mentor: Dr. Linda Resar

HMGA1 Chromatin Regulators in Clonal Hematopoiesis and Cardiovascular Disease

Modulation of Rescue Competent MicroRNAs in Cystic Fibrosis Lungs

3D Model and In-Line Assessment of Colon based on iPS Cells for Ulcerative Colitis Treatment

Investigating H3K4 Methylation Pathway Targets in Human Stem Cell Models of Schizophrenia and SETD1A Haploinsufficiency

Use of Extracellular Vesicles from Metabolically-Engineered Mesenchymal Stem Cells for Prolonged Organ Preservation in Heart Transplantation

Rejuvenate Hematopoietic Stem Cells by Counteracting the Alcohol-Induced Aging Process

Stem cell Model of mTORopathies

Inferring the Mechanistic Regulation of Human Hematopoietic Stem-Progenitor Cells During Standard and ROS-induced States

Enhancing Mesenchymal Stem Cells Intrinsic Expression of IL-10 and MMP-9 to Augment  Capacities for the Treatment of Liver Diseases

LBSL iPSC Brain Modeling: A Prototype for Pediatric Rare Disease

Effects of Innate Immune Signaling on Ischemia-Reperfusion Tolerance of Human Stem Cell-Derived Cardiomyocytes

Leveraging Innervated Human Cardioids to Study Cardiac Disease

GMP OsteoAdapt Manufacturing Facility in Maryland

Mobile Cleanroom-Based Manufacturing of Genetically Engineered Cellular Products

Establish Vita In-House GMP Manufacturing in Maryland to Deliver Cost-Effective Therapeutics

Development of a Closed Extracellular Vesicle (EV)/Exosome Drug Substance/Product Manufacturing Process without Sterile Filtration

A Mesenchymal Stem Cell Containing Matrix for Nonalcoholic Steatohepatitis (NASH)

Simplified Solution for Enhanced Production of High Purity Extracellular Vesicles from Mesenchymal Stem Cells

Growing Exogenous Human Liver in Pigs

Autologous Volar Fibroblast Injection into the Stump Site of Amputees

Extracorporeal Mesenchymal Stem Cell Therapy (SBI-101) in Severe Sepsis Complicated by Acute Kidney Injury

Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures

Mechanism of Action of Adipose-Derived Stem Cells in Oxygen-Enhanced Bone Regeneration

Developing A Stem Cell Model of Epigenetic Dysregulation in Huntington's Disease

Generation and Characterization of Human Mrgprx1+ Sensory Neurons for Developing Novel Anti-Pain Therapies

Amniotic Fluid Derived Stem Cells for the Treatment of Necrotizing Enterocolitis in Premature Infants

A Human Retinal Organoid Model to Study Retinal Ganglion Cell Biology

Validation of Ripk2 Kinase As A Novel Therapeutic Target for Alzheimers Disease

Mobilization of Skin Resident Stem Cells to Drive Skin Growth

Cardiolipin Modification In iPSCs: Developing A Treatment for Tissue-Specific Mitochondrial Defects In Barth Syndrome

Intraarterial Administration of Human MSCs Secreting P2X7-Blocking Nanobody as Adjuvant Therapy for Acute Stroke

Investigating A Novel Signaling Pathway in iPSC-Derived Models of Tau-Associated Neurodegeneration

Mentor: Dr. Aaron James

Exploration of Human Perivascular Stem Cell Diversity

Development of Patient iPSC-derived Organoid Models for Beck-Fahrner Syndrome: Probing DNA Methylation and Advancing Treatment

Intravital 2-Photon Imaging Human iPSC-Derived Progenitors Grafted into Ischemic Mouse Brain Assisted by Helper Cells

Intravascular Bioreactor Delivery of Anti-Inflammatory Paracrine Factors to Treat Acute Respiratory Distress Syndrome

Generating Human Liver in Pigs: Meeting a Growing Unmet Need

The RECOVER Trial:  Longeveron Mesenchymal Stem Cells (LMSCs) for ARDS due to COVID-19 and Flu

New Therapeutic Targets for Prevention and Treatment of GBA1-Associated Parkinson's Disease

3D Culture and Differentiation of Human iPSCs for Cardiac Tissue Engineering and Regeneration

Targeting Osteogenic Inhibitors within Human Pericytes

Modeling Congenital Diaphragmatic Hernia Lung Development with Stem Cell-Derived Organoids

Developing CRISPR Technology to Rejuvenate Blood Stem Cells

Using Non-Canonical Amino Acids to Repair hERG LQT2 Mutants in hiPSC-CMs

Mentor: Dr. Elias Zambidis

Epigenetic Regulation of Vascular Differentiation from Human Nave Pluripotent Stem Cells

Mentor: Dr. Sharon Gerecht

3D In Vitro and In Vivo Models to Study Vascular Graft Remodeling in Atherosclerosis

Mentor: Dr. Donald Zack

Long Range Transcriptomic Analysis of Human Retinal Development and Degeneration

Mentor: Dr. Jeff WM Bulte

In vivo Imaging of Stem Cell-Derived Extracellular Vesicles using Positive Contrast MRI

Mentor: Dr. Valina Dawson

Tunable Biomaterial Guided Stroke Repairs by Endogenous and Exogenous Stem Cells

Mentor: Dr. Hanseok Ko

Neurotoxic Astrocyte Secreted-ExoDrp1 Causes Excessive Mitochondrial Fragmentation and Neurodegeneration of Human Dopaminergic Neurons

Mentor: Dr. Luo Gu

Dynamic Hydrogel Matrix to Prime Mesenchymal Stem Cells for Enhanced Autoimmune Diseases Treatment

Mentor: Dr. Warren Grayson

Building a Predictive Computational Bone Regeneration Model to Optimize the Application of Stem Cells

Leveraging an iPSC-Derived Model of Acquired Sideroblastic Anemia for Novel Therapies

Identification and Application of Distinct Perivascular Stem Cell Sub-Populations to Rotator Cuff Repair

Role of E-cadherin in the Intestinal Stem Cell Homeostasis and Regeneration

Mechanisms of Fibrosis in Dilated Cardiomyopathy

Exosomes Derived from Engineered Human iPSCs for the Therapy of Huntington's Disease

Satellite Stem Cell Therapy for Limb-Girdle Muscular Dystrophy

Neonatal Cardiac Stem Cells for Heart Tissue Regeneration

Apical Surface-Outward (ASO) Airway Organoids: A Novel Cell System for Drug Discovery and Personalized Medicine

Building a Commercial Neural Cell Bank from Patient-Derived Induced Pluripotent Stem Cells

Autologous Volar Fibroblast Injection into the Stump Site of Amputees

Engraftment of Human iPSC Derived Neural Progenitors in Mouse for Developing Treatments for Alzheimers Disease

Chemoproteomic Immunophenotyping of Human Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells

Developing MPI for Tracer-Based, Non-Radioactive, and Quantitative Whole Body Imaging of Cell Delivery

Human iPSC-Derived NF-kB p50-Deficient Myeloid Cell Immunotherapy for Cancer

A Novel Mechanism of Immune Evasion by Human Neonatal Cardiac Progenitor Cells

Developing Human iPSC-Derived Exosome Therapy to Improve Recovery after Peripheral Nerve Injury

Targeting an Activated Microglia/Astrocyte Axis for Reducing Neurodegeneration

A Stem Cell-Derived Human Neuron Model to Explore Treatments of Axonopathies

Developing Stem Cell Therapy for Bone Loss and Fractures with Aging

CHMP7 in the Initiation of Nuclear Pore Injury in C9orf72 ALS/FTD and Sporadic ALS

Universal Donor Naive Vascular Progenitors for Regenerative Medicine

An Isogenic HiPSC-Derived Cortical-Striatal Co-Culture System to Investigate Transneuronal Propagation of Mutant Huntingtin in HD

Regenerative Cell Therapies for Soft Tissue Restoration