The Maryland Stem Cell Research Fund (MSCRF) is focused on identifying and fostering cutting-edge research and innovation in the field of regenerative medicine in Maryland. Our Accelerating Cures initiative comprises programs that help transition human stem cell-based technologies from the bench to the bedside as well as mechanisms to build and grow stem cell companies in Maryland. Since 2007, MSCRF has invested over $164 million in accelerating stem cell research, cures and commercialization, in addition to building a collaborative stem cell community in our region. Below is a list of our most current awardees.
2021
Intravascular Bioreactor Delivery of Anti-Inflammatory Paracrine Factors to Treat Acute Respiratory Distress Syndrome
Generating Human Liver in Pigs: Meeting a Growing Unmet Need
The RECOVER Trial: Longeveron Mesenchymal Stem Cells (LMSCs) for ARDS due to COVID-19 and Flu
2020
Apical Surface-Outward (ASO) Airway Organoids: A Novel Cell System for Drug Discovery and Personalized Medicine
Building a Commercial Neural Cell Bank from Patient-Derived Induced Pluripotent Stem Cells
Autologous Volar Fibroblast Injection into the Stump Site of Amputees
Engraftment of Human iPSC Derived Neural Progenitors in Mouse for Developing Treatments for Alzheimers Disease
Validation of Pluripotent Stem Cell-Derived Corneal Endothelial Cells for Donor-Free Corneal Endothelial Keratoplasty
Chemoproteomic Immunophenotyping of Human Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells
Developing MPI for Tracer-Based, Non-Radioactive, and Quantitative Whole Body Imaging of Cell Delivery
Human iPSC-Derived NF-kB p50-Deficient Myeloid Cell Immunotherapy for Cancer
Engineering Stem Cell Microenvironment for Image-guided Therapeutic Intervention
A Novel Mechanism of Immune Evasion by Human Neonatal Cardiac Progenitor Cells
Developing Human iPSC-Derived Exosome Therapy to Improve Recovery after Peripheral Nerve Injury
Leveraging Novel SIX1 Transcription Factor Network Interactions to Stimulate Human Erythropoiesis
Targeting an Activated Microglia/Astrocyte Axis for Reducing Neurodegeneration
A Stem Cell-Derived Human Neuron Model to Explore Treatments of Axonopathies
Developing Stem Cell Therapy for Bone Loss and Fractures with Aging
CHMP7 in the Initiation of Nuclear Pore Injury in C9orf72 ALS/FTD and Sporadic ALS
Universal Donor Naive Vascular Progenitors for Regenerative Medicine
Mentor: Dr. John Fisher
Engineering the Human Joint Microenvironment to Understand the Mechanism of Cellular Senescence and Stem Cell Aging
Mentor: Dr. Jennifer Erwin
Dissecting the Pathological Molecular Mechanisms Underlying X-Linked Dystonia-Parkinsonism with Patient iPSC-Derived Striatal Organoids
Mentor: Dr. Steven Jay
Engineering Potency and Delivery of Oligodendrocyte-Derived Extracellular Vesicles for Spinal Cord Injury
Mentor: Dr. Valina Dawson
RNA Velocity of Single Nuclei in Parkinson Disease
Mentor: Dr. Gabsang Lee
Human iPSC-Derived Myelinating Schwann Cell-Based Disease Modeling and Efficient Differentiation Study
An Isogenic HiPSC-Derived Cortical-Striatal Co-Culture System to Investigate Transneuronal Propagation of Mutant Huntingtin in HD
Human iPSC-derived EGFR+ functional Schwann Cells to Enhance Nerve Regeneration and Improve Functional Outcomes in VCA
2019
Development of a Biphasic MSC Delivery System for the Repair of Osteochondral Defects
Stem Cell Loaded Extracellular Matrix Replacement Scaffolds for Skin Regeneration in Burns
Application of Mesenchymal Stem Cell Spheroids in an Implantable Bioreactor
Molecular, Neurodevelopmental, Connectomic, and Behavioral Consequences of a Psychiatric Risk Gene in a Population Isolate
Enhancing TFEB Activity to Ameliorate Neurodegenerative Changes in iPSC Models of Parkinson's Disease
Single Cell RNA-Seq of Intestinal Stem Cells in the Generation of a Humanized Artificial Intestine
Reduced Graphene Oxide (rGO)-Mattress System for High-Throughput iPSC-Derived Cardiomyocyte-Based Screening Platform
CD107a Divides Fat From Bone-Forming Progenitors Within Adipose Tissue
Image-Guided, Intra-Arterial Delivery of Human MSC-Derived Extracellular Vesicles for Treatment of Ischemic Stroke
A Gene Regulatory Network Controlling Human iPSC-Myocyte Maturation
Vascularized Hydrogel System Modeling Neural Networks in Autism Suitable for High Throughput Screening
Inhibition of the PARK10 gene USP24 As A Neuroprotective Treatment in Parkinson's Disease
Resistance of Pathologic alpha-Synuclein in LAG3 Deficient Human Dopaminergic Neurons
iPSC-spinal Cord Astrocyte/Motor Neuron Co-Culture Platform Investigating Hemichannel-Mediated Toxicity and Neuroprotection in Amyotrophic Lateral Sclerosis
An Engineered Orthogonal Growth Factor for Targeted Stimulation of Bone Repair
Role of Mechanobiological Forces in Engineering Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells
Mentor: Dr. Piotr Walczak
Transplantation of Stem Cells to Prevent Brain Toxicity Following High-Dose Intraarterial Chemotherapy of Glioblastoma
Mentor: Dr. Seth Blackshaw
Directed Differentiation of Human Hypothalamic Neurons that Regulate Sleep
Mentor: Dr. Linzhao Cheng
Investigating the Therapeutic Potential of Human iPSC-Derived Extracellular Vesicles In-Vitro and In-Vivo
Mentor: Dr. Ahmet Hoke
Studying PMP22 Function in HNPP and CMT1A iPSC-Derived Schwann Cells
Mentor: Dr. Sharon Gerecht
The Role of Mechanosensing Towards the Treatment of Age Mediated Vascular Diseases
Mentor: Dr. Nicholas Maragakis
Regional Diversity of hIPSC-Derived Astrocytes and its Contribution to Non-Cell Autonomous Toxicity in ALS
Mentor: Dr. Chulan Kwon
Multiplexed Gene Knock-in with CRISPR/Cas9 in Human Pluripotent Stem Cells
